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This oxidative stress caused by alcohol reduces the production of glutathione, leading to lower levels in the body

It is important to note that the majority of this mechanistic research has been conducted in cell culture and animal models, with a significant proportion originating from a single research group

GRX1 deficiency in liver cancer cells increases oxidative modifications and autophagic flux, while PRDX6-mediated GRX1 upregulation suppresses autophagy (54)

To induce Ire1 deficiency, 8-week old Ern1 f/f ;Rosa26-CreERT2 + mice were injected with 75 mg/kg tamoxifen (Sigma Aldrich) dissolved in corn oil (Sigma Aldrich) for 5 consecutive days and subjected to the IRI procedure after 2 weeks