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A recent clinical study further confirmed that NSW disrupts 24-hour rhythms of PER2, PER3, BMAL1, and ESR2 in PBMCs, impairs the inverse correlation between PER2 and BMAL1, and alters PER1 and ESR1 expression patterns, highlighting a misalignment in the peripheral circadian network associated with NSW schedules 212

Within the ANCOVA, the least-squares (LS) mean differences between the renal impairment group and the normal-to-match group, along with 90% confidence intervals for the differences, were estimated