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the invention provides a compound of formula (I), its stereoisomers and/or its pharmaceutically acceptable salts or a pharmaceutical composition comprising the compound, its stereoisomers and/or its pharmaceutically acceptable salts for use in the prevention or treatment of a disease or disorder associated with impaired physical and/or immunological barrier functions of the skin

In total, we generated six LMNA transgenic zebrafish lines: LMNA (WT), 3 novel and 2 known pathogenic mutant lines, including LMNA (L35P), LMNA (E358K), LMNA (R453W), LMNA (W520G), and LMNA (A539V), and which were validated by fin-clip, and the presence of the intended mutations was confirmed by comparing them to the LMNA (WT) sequence (Fig