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This study used one dose of suramin and resulted in a significant difference in kids that received Suramin, but no difference in placebo group

Stopping treatment entirely (because B12, MMA or homocysteine values are back to standard) without the causes having been removed is not the correct way of treating a patient

UniProt: the universal protein knowledgebase in 2023

Several studies have reported increased melatonin production following treatment, particularly in older individuals with age-related declines in pineal function [11]