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Trichloroethene exposure induces autoimmune reactions, leading to increased apoptosis, immune activation and the upregulation of PARP-1 expression following the development of anti-single-stranded DNA antibodies (78)

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

The top ten specific and enriched CNAs identified from the METABRIC and TCGA datasets are underlined

HOW INFLAMMATION LEADS TO DEPRESSION The evidence summarized in Table 2 highlights the established knowledge and recent evidence on how genetic predisposition and early life stress form a vulnerability for chronic immune dysregulation later in life, while acute infections, autoimmune disease and adverse lifestyle/metabolic factors act as triggers of sustained inflammation