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The NIH Office of Dietary Supplements has consistently stated in its professional fact sheets that there is no evidence supplementation in adequate individuals boosts metabolism or promotes fat loss

Under hypoxic conditions, apigenin treatment in gastric cancer (AGS and SNU-638) cells enhances phosphorylation of ATG5, LC3-II, AMP-activated protein kinase (AMPK), and unc-51 like autophagy activating kinase 1 (ULK1), while simultaneously down-regulating p62, collectively driving autophagy-mediated cell death [71]