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Amyotrophic lateral sclerosis: translating genetic discoveries into therapies

Where this fits in a broader integrative model I also think it helps to place nebulized glutathione in a larger framework of restorative medicine

However, the measurement of the ratio of [GSH]:[GSSG] in an intracellular organelle is fraught with technical difficulties

For instance, inhibition of MCT1 disrupts lactate homeostasis and impairs both glycolytic flux and GSH biosynthesis in MYC-driven cancer, resulting in reduced glucose uptake and depletion of ATP, NADPH and GSH (50)