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Regulatory responses may include infringement notices, product seizures, import interventions and, where appropriate, civil or criminal penalties

Similar to NFE2L2, xCT is positively regulated by ATF4 and serves a pivotal role in reducing ferroptosis-induced ROS production in glioblastoma multiforme cells

The discovery of drugs that target particular pathogenic pathways should be further evidenced by experimental studies for a better knowledge of the disease heterogeneity and molecular mechanisms underlying the pathogenesis of SLE ( Proper first-line treatment should also be recommended for these patients, involving immunosuppressive medications such as mycophenolate mofetil (MMF), azathioprine (AZA), methotrexate (MTX), and cyclophosphamide (CYC)