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Supplementary material The Supplementary Material for this article can be found online at: Footnotes References 1 Al-RawithiS.El-YazigiA.ErnstP.Al-FiarF.NichollsP

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Differential gene expression analysis was performed on the different subgroups with a base mean value of expression greater than 1, log2 fold change greater than 0.6 and an adjusted p -value less than 0.1 using the DESeq2 pipeline 124