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Oxidative stress, in turn, leads to many diseases including cancer, cardiac disorders, neurodegenerative disorder immune and metabolic disorders, and accelerates aging

HBV capsid assembly has been reported to be facilitated by ROS with heat shock protein 90, enhancing viral replication 85

Pdh, Odh, and Bckdh Pdh and Odh are multienzyme complexes that utilize various cofactors and coenzymes including thiamine pyrophosphate (TPP, E 1 ), lipoic acid (E 2 ), coenzyme A (CoASH, E 2 substrate), FAD (E 3 ), and NAD (E 3 substrate) to catalyze the conversion of pyruvate (Pdh) or 2-oxoglutarate into acetyl-CoA or succinyl-CoA, respectively (McLain et al., 2011)