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However, whether oral bioavailability translates meaningfully to humans has not been established in clinical trials

This material is not a drug, food, cosmetic, dietary supplement, or medical device and has not been evaluated by the FDA

Eur J Pharmacol 570:212221 Malavaud B, Tack I, Jonca F, Praddaude F, Moro F, Ader JL, Plouet J (1997) Activation of Flk-1/KDR mediates angiogenesis but not hypotension