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[0353] Using the sequence information provided herein, the anti-ALPPL2 specific antibodies described herein (e.g., M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS, M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P, M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25ASwt, M25AVIA, M25AVLF, M25ALIA, M25ALLF, M25wtIA, and/or M25wtLF), or variants thereof, can be chemically synthesized using well known methods of peptide synthesis

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The fact, that MPO deficient neutrophils are generally effective at killing microbes, albeit with a slower rate, indicates that the major NADPH oxidase products, superoxide and H 2 O 2 , must compensate for the lack of MPO and MPO-derived oxidants, and thus, be responsible for the observed killing activity