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We screened the active metabolites in sea buckthorn and identified 30 metabolites that have therapeutic effects on digestive system diseases, which are listed in Table 1

Auxin acts as a downstream signaling molecule involved in hydrogen sulfide-induced chilling tolerance in cucumber

Abbreviations 53BP1: P53-binding protein 1 6-TG: 6-Thioguanine -TrCP: -Transducin repeat-containing protein ABC: ATP-binding cassette AhR: Aryl hydrocarbon receptor AMFR: Autocrine motility factor receptor AML: Acute myeloid leukemia AMPK- 1: AMP-activated protein kinase 1 ANAPC2: Anaphase-promoting complex subunit 2 APAF-1: Apoptotic protease activating factor 1 ASPM: Abnormal spindle-like microcephaly-associated protein ATTEC: Autophagosome-tethering compound AUTAC: Autophagy-targeting chimera BCA2: Breast cancer-associated gene 2 BCL-2: B cell lymphoma 2 BCRP: Breast cancer resistance protein BET: Bromodomain and extra-terminal BIRC3: Baculoviral IAP repeat-containing 3 BRCA1: Breast cancer type 1 susceptibility protein Cbl-b: Casitas b-lineage lymphoma-b CDC25A: Cell division cycle 25 A CDK: Cyclin-dependent kinase CGRRF1: Cell growth regulator with RING finger domain protein 1 CHIP: C-terminus of HSC70-interacting protein CHK: Checkpoint kinase CRL4: Cullin-RING ubiquitin ligases 4 CYP450: Cytochrome P450 enzymes CMA: Chaperone-mediated autophagy CSC: Cancer stem cell CTM: CMA-targeting motif CYLD: Cylindromatosis-associated DUB CYPA: Cyclophilin A DAB2IP: DOC-2/DAB2 interactive protein DDR: DNA damage response DNA-PKcs: DNA-dependent protein kinase catalytic subunit DSB: DNA double-strand break DUB: Deubiquitylating enzyme EGFR: Epidermal growth factor receptor EMT: Epithelial-to-mesenchymal transition ERAD: Endoplasmic reticulum-associated degradation ERK: Extracellular signal-regulated kinase FLIP: FLICE-inhibitory protein GAS: Group A Streptococcus GBM: Glioblastoma GDP: Guanosine diphosphate GSK3 : Glycogen synthase kinase 3 GST: Glutathione S-transferase HBXIP: Hepatitis B virus X-interacting protein HCC: Hepatocellular carcinoma HECT: Homologous to the E6AP C-terminus HMGCoAR: 3-Hydroxy-3-methylglutaryl-coenzyme A reductase HOXB13: Homeobox B13 HIF-1 : Hypoxia-inducible factor 1 alpha HR: Homologous recombination IAPs: Inhibitors of apoptosis proteins IKK: Inhibitor of NF- B kinase JAK: Janus kinase JNK: C-Jun N -terminal kinase KEAP1: Kelch-like ECH-associated protein 1 KRAS: Kirsten rat sarcoma LAMP2A: Lysosome-associated membrane protein type 2A LSCC: Lung squamous cell carcinoma LUAD: Lung adenocarcinoma LYTAC: Lysosome-targeting chimera LZTR1: Leucine zipper-like transcriptional regulator 1 MAPK: Mitogenactivated protein kinase MARCH: Membrane-associated RING-CH MDC1: Mediator of DNA damage checkpoint protein 1 MDM2: Mouse double minute 2 homolog MAST: Microtubule-associated serine/threonine kinase 1 MDR: Multi-drug resistance MKP1: Mitogen-activated protein kinase phosphatase-1 MRP: MDR-associated protein MORC2: Microrchidia family CW-type zinc finger 2 MM: Multiple myeloma MMR: Mismatch repair MSH2: MutS protein homolog 2 MT: Methyltransferase MTAP: Methylthioadenosine phosphorylase NAT: N -Acetyltransferase NEDD4L: Neural precursor cell expressed developmentally downregulated gene 4-like NHEJ: Nonhomologous end-joining NPC: Nasopharyngeal carcinoma NRF2: Nuclear factor erythroid 2-related factor 2 NSCLC: Non-small-cell lung carcinoma PARP: Poly (ADP-ribose) polymerases PBX1: Pre-B-cell leukemia homeobox-1 PCa: Prostate cancer PI3K: Phosphoinositide 3-kinase PLK: Polo-like kinase PRKACA: Protein kinase cAMP-activated catalytic subunit alpha PP2A: Protein phosphatase 2A PRMT5: Protein arginine methyltransferase 5 PROTAC: Proteolysis targeting chimera PUMA: P53 upregulated modulator of apoptosis pVHL: Von HippelLindau protein RBX1: DOC-2/DAB2 interactive protein 1 RBR: RING-between-RING RING: Really interesting new gene ROS: Reactive oxygen species SCF: SKP1/CUL1/F-box SGCE: Sarcoglycan epsilon SH3RF1: SH3 domain-containing RING finger 1 SIRT1: Sirtuin 1 SKP1: S-phase kinase-associated protein 1 SMURF2: Smad ubiquitination regulatory factor 2 SNIPERs: Specific non-genetic IAP-based protein erasers SOCS5: Suppressor of cytokine signaling 5 STAT: Signal transducer and activator of transcription SULT: Sulfotransferase STUB1: STIP1 homology and U-Box-containing protein 1 TPD: Targeted protein degradation TRIM15: Tripartite motif-containing protein 15 TKI: Tyrosine kinase inhibitor TNBC: Triple-negative breast cancer UBE2R1: Ubiquitin-conjugating enzyme E2 R1 UCHL3: Ubiquitin C-terminal hydrolase L3 UGT: UDP-glucuronosyltransferase USP: Ubiquitin-specific peptidase UV: Ultraviolet VCP: Valosin-containing protein XRCC4: X-ray repair cross-complementing protein 4 YAP: Yes-associated protein References Siegel RL, Miller KD, Fuchs HE, Jemal A

10.1007/s00253-008-1729-2