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Currently, the overall prognosis for endocrine-independent prostate carcinoma/castration-resistant prostate cancer (CRPC) remains poor due to its insensitivity to androgen deprivation therapy and highly aggressive nature [13,14]

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Competing interests: All authors have read and approved of the contents of the manuscript and none of the authors have competing financial interests

score 2: less than 50% higher cellularity of ribbon-oriented round nucleus cells