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Additional preclinical investigation using humanized animal models and in vitro models of cell cultures, organoids, and organs-on-chips comparing the benefits of the combined action of vitamin B5 and vitamin U versus their effects alone might greatly impact the justification of combined therapy

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While DPP-IV is effective at cleaving proline bonds, it is an exopeptidase , meaning it can only snip amino acids from the external ends of the long protein chain