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Such reactive astrocytes are characterized by reduced glutamate uptake capacity and increased release of pro-inflammatory cytokines, including TNF- and IL-1, which contribute to synaptic dysfunction and neuronal injury

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The GluN3 subunits form a functional triheteromeric complex with GluN1 and either GluN2A (in neurons and hippocampus), GluN2B (neurons), or GluN2C (in oligodendrocytes) subunits imparting biochemical/electrophysiological properties that are unique from the GluN2-containing receptors 38-40

T lymphocytes that take up mitochondria released from cancer cells often display impaired effector functions, contributing to weakened antitumor immunity [103]