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Several TRK inhibitors, including Entrectinib [20], Larotrectinib [21] or Repotrectinib [22, 23], have shown impressive responses in cancers with rearranged NTRK, including lung, colorectal, thyroid, neuroblastoma, gastric carcinoma, and pediatric cancers

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19 The mean change in body weight from baseline to week 68 was 14.9% in the semaglutide group compared with 2.4% with placebo, for an estimated treatment difference of 12.4 percentage points (95% confidence interval [CI], 13.4 to 11.5

A comprehensive literature search was conducted in PubMed, Scopus, Embase, and Web of Science, covering studies published between December 2019 and August 2025