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Lipid metabolism pathways, particularly steroid hormone biosynthesis and cholesterol metabolism, were highly enriched across all three iHLO development phases, indicating the organoids capacity to process lipids, especially cholesterol

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We can see that women with reduced GSH levels who demonstrate a risk of moderate/severe suicide were in the mood disorder group, despite knowing that psychiatric disorders alter the brain redox state (31), the effect observed in our study (GSH levels) is not only of these disorders but related to the risk of suicide (mainly outcome), since most women in the mood disorder group are at no risk for suicide and without changes in GSH levels

For cartilage research applications, dosing protocols are still being established from preclinical data most published work uses in vitro concentrations rather than in vivo doses