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This is then synthesized and validated by cell-based assays, which greatly reduces the time cost of preclinical development of nanomedicine carriers

Therefore, the aim of this review was to summarize the recent investigations revealing the mechanistic roles of ferroptosis and non-ferroptosis pathways in CT side effect toxicity in preclinical studies, with an overall emphasis on the inhibition of these pathways by ginger rhizome extract, 6G and ZG, as reported in the preclinical literature

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First, we increased cellular levels of GSH in leaves of healthy, non-inoculated wild type Xanthi NN and SA-deficient NahG tobacco plants by exogenous GSH and OTC treatments and monitored changes in free and bound SA levels