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Research Use Only This product is a chemical reference material for in-vitro laboratory use only

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The majority of tumours develop acquired chemotherapy resistance, where an initially chemosensitive tumour adapts in response to chemotherapy through various mechanisms including: (i) increased cell viability which can be directly triggered by impaired apoptosis or increased proliferation [19], (ii) improved DNA repair [19], (iii) increased drug efflux and altered drug metabolism [19,20,21], (iv) propagation of cancer stem cells [22], (v) increased invasive potential [23] and (vi) increased tumour hypoxia with altered angiogenesis [24]