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5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme upregulated in adipose tissue that suppresses fat oxidation and energy exp

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262 A trial involving 30 fibromyalgia patients reported 200 mg of intramuscular plus 400 mg of oral SAMe daily for six weeks was more effective than transcutaneous electrical nerve stimulation (TENS) for reducing tender points, pain and fatigue, and depression and anxiety scores