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Understanding and managing different types of pain in Myalgic Encephalomyelitis (ME) ABSTRACTS 2025 Movement Disorders Clinical Practice Wiley Online Library Post Exertional Neuroimmune Exhaustion. CFS uses PEM or 'Post Exertion Malaise' a vague feeling of discomfort or fatigue is an inaccurate and inadequate word for the pathological low threshold fatigability and postexertional Exploring the Role of Neurotransmitters in Multiple Sclerosis: An Expanded Review ACS Chemical Neuroscience

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10.1523/JNEUROSCI.18-23-09620.1998 112 LewerenzJ.MaherP.MethnerA

Studies suggest this rebalancing occurs through effects on thymic peptide signaling and restoration of neuroendocrine-immune system communication that deteriorates with aging