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doi: 10.3390/ijms20051033 182 GiordanoATommonaroG

Selenocysteine A selenium analogue of cysteine, where selenium replaces sulfur

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Although strategies such as iron chelators (e.g., deferoxamine), antioxidants (e.g., N-acetylcysteine), and GPX4 activation demonstrate neuroprotective potential in animal and cellular models, their safety, tolerability, blood-brain barrier permeability, and ability to modulate disease progression in humans have not been systematically validated