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While most men tolerate B12 well, those with Lebers disease (a rare genetic eye disorder) should avoid injections, as high doses of B12 may worsen symptoms

For joint-related conditions, documentation may specify an unspecified site, such as unspecified knee, unspecified shoulder, unspecified elbow, unspecified wrist, unspecified hip, or unspecified ankle, as applicable to the patients diagnosis and organ or system involvement

[8] Development of AOD9604 was halted following poor efficacy in a later 24 week trial

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