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Enhanced expression of CD47 is associated with off-target resistance to tyrosine kinase inhibitor gefitinib in NSCLC

Ichimura Y, Habuchi T, Tsuchiya N, Wang L, Oyama C, Sato K, et al

Glutamine-derived -KG can enter the TCA cycle to produce energy for the cell or proceed backwards via the reductive carboxylation to provide an alternative source of lipid synthesis