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Down-regulation of DJ-1 augments neuroinflammation via Nrf2/Trx1/NLRP3 axis in MPTP-induced Parkinson's disease mouse model

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Although length of treatment and experimental model differed per study, all observed a drop in ATP levels and a depletion of NAD following exposure to high-dose VitC, in line with the inhibition of energy metabolism and multifaceted metabolic rewiring described in numerous pre-clinical studies using alternative approaches