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The causal relationship between gut microbiota and SLE has not been fully established, and the precise mechanisms by which microbial metabolites regulate immune responses require further elucidation

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The intracellular proteins could reflect transfer from tumor cells to immune cells through extracellular vesicles, mitochondriaplasma membrane interactions 39 or tunneling nanotubes 40 or they could be artifacts from nonspecific binding due to our use of the monoculture (rather than coculture) no-LaccID negative control for data filtering (Fig