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ClinicalTrials.gov (2026) Related Dosing Protocols Educational use only This guide is an educational research reference, not medical advice or a treatment plan

Advantage: Potential for higher bioavailability than standard oral ingestion Challenge: Peptides are poorly absorbed through intact mucosal membranes without transport mechanisms Evidence: No studies confirm enhanced sublingual bioavailability for Dihexa Standard oral (swallowed): Tablets swallowed with water, absorbed through the gastrointestinal tract

PAI-1, a serine protease inhibitor and another factor involved in the pathogenesis of stroke is produced primarily by the endothelium which directly acts as an active inhibitor of tPA and urokinase (uPA), a serine protease which is responsible for cleaving plasminogen to plasmin (Lakhan et al., 2013)

& Bao, G