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202,203 Ferroptosis can occur by targeting two main pathways, the extrinsic or transporter (e.g., SLC7A11, SLC38A1, NOXs and TFRC)-dependent pathway and the intrinsic or enzyme (e.g., ACSL4, ALOXs, GPX4, POR, GCH1, NOS and AIFM2)-regulated pathway

The complexity of an active sequence of a biological macromolecule (e.g., polynucleotides, polypeptides, and molecules that are comprised of both polynucleotide and polypeptide sequences) has been called its information content ("IC"), which has been defined as the resistance of the active protein to amino acid sequence variation (calculated from the minimum number of invariable amino acids (bits) required to describe a family of related sequences with the same function)

These findings confirm that PRMT7-mediated GLUD1 methylation at R76 residue improves its protein stability by supressing GLUD1 ubiquitin-dependent degradation

Molecular interaction studies