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This mechanistic insight led to the discovery of the GSH precursor N -acetylcysteine (NAC) as an effective antidote against APAP toxicity in mice and in patients [10, 11]

Lai 6 and Michael Li 7 , (1)University of California, San Francisco, (2)PSC Partners Seeking a Cure, (3)PSC Partners Seeking a Cure Canada, (4)University of California Davis, Sacramento, CA, (5)University of North Carolina, (6)University of California-San Francisco, San Francisco, CA, (7)University of California San Francisco Background: Patients with primary sclerosing cholangitis (PSC) experience numerous symptoms that impact quality of life

The potential LXR agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons

Noteworthy, the native host does not produce any methylated terpenoid compounds