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Another way of considering the chemical basis of these complementary approaches is to note that in procedure A, we leverage the fact that in solution, the deprotonated terminal perthiolate and perthiolate-like sulfur atoms in polysulfides have nucleophilic chemical properties and thus react with IAM/IAM-TPP

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Recent studies have highlighted key molecular targets such as SREBP (Yue et al., 2021), AMPK (Lu et al., 2016), NF-B (Ren et al., 2020) as mechanisms by which Chinese botanical drugs regulate lipid metabolism in the liver

ESMO Ann Oncol