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For the purposes of this review, memory will be the primary domain of interest due to its intimate relationship with MCI and ADRD

Res Pharm Sci 6:111 Yamaguchi S, Wiessner JH, Hasegawa AT et al (2005) Study of a rat model for calcium oxalate crystal formation without severe renal damage in selected conditions

It has also been studied in a phase I trial (NCT02256631) in combination with VRC01 and another variant of VRC01, VRC07-532LS (ref

However, in a much larger randomized controlled trial of simvastatin and an antioxidant combination of 600 mg of all - rac --tocopherol (297 mg of RRR --tocopherol), 250 mg of vitamin C, and 20 mg of -carotene daily) in more than 20,000 men and women with CHD or diabetes mellitus, the antioxidant combination did not adversely affect the cardioprotective effects of simvastatin therapy over a five-year period (131)