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Figure 4 Mitochondrial superoxide is an important intracellular source of reactive oxygen species and plays a critical role in promoting Fenton/Haber-Weiss reactions by releasing iron from intracellular ferritin complex, which in turn culminates in the generation of highly reactive hydroxyl radicals (6973)

Finally, NETosis requires both oxidative burst and PAD4 activation, events are dispensable for apoptosis

MedChemComm 10(9):15311544 Bennicia G, Almahasheer H, Alghrably M et al (2024) Mitigating diabetes associated with reactive oxygen species (ROS) and protein aggregation through Pharmacological interventions