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It is also able to increase the bodys tolerance to toxic substances

doi: 10.1210/en.2007-1292 57 BunckMCEliassonBCornrAHeineRJShaginianRMTaskinenM-Ret al

Mechanistically, we showed that system x C blockade in conjunction with APR-246, synergistically depleted intracellular GSH, resulting in mitochondrial ROS accumulation, lipid peroxidation and ultimately apoptotic cell death (Fig