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Administration of amino acids to complex I or complex II mutant worms revealed that complex I activity is required for complete serine- and histidine-mediated life extension, while complex II activity is required for proline-mediated life extension (Edwards et al., 2015)

In particular, excessive intake of Vitamin B6 can cause nerve damage, and too much Niacin may lead to liver damage

Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses

Understanding Vitamin B12 Deficiency Vitamin B12 deficiency occurs when your body lacks enough of this essential nutrient, leading to symptoms like: Persistent fatigue Weakness and lightheadedness Numbness or tingling in hands and feet Memory problems and difficulty concentrating Mood changes, including irritability and depression Certain factors increase your risk, such as age, certain medications, digestive conditions, and restrictive diets