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With aging and cardiometabolic stressorsincluding sustained blood-pressure load, glucose variability, dyslipidemia, smoking, excess weight, inactivity, and disrupted sleepthe endothelium may shift from a protective state toward a dysfunctional one

Both the drugs demonstrated a high affinity for their respectively identified protein targets based on molecular docking which indicate their potential to be targeted using antioxidants which can be administered as adjunct therapy to mitigate oxidative stress during epilepsy