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In untreated or poorly transfused patients: Stunted growth Hepatosplenomegaly Development of masses due to extramedullary hematopoiesis Skeletal changes Thalassemia major They require regular GR transfusions

Through enzymatic hydrolysis (Figure 5), animal waste proteins can be decomposed into free amino acids and peptides, which are high-value substances used to develop new healthy foods as additives and functional ingredients and produce food-grade enzymes (Figure 7) (Sila and Bougatef, 2016

The functional capacity of the GSH system is determined not only by the size of the intracellular GSH pool but also by the efficiency of GSH regeneration from GSSG