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This promotes Nrf2 nuclear translocation and ARE binding, upregulating antioxidant enzymes such as Superoxide Dismutase 1(SOD1), Heme Oxygenase-1(HO-1), and Glutathione Peroxidase (GPx) (Wang et al., 2020

[7] This is why the two are frequently studied as complementary rather than competing mechanisms: the entire rationale for the CagriSema combination is that pairing an amylin analog (cagrilintide) with a GLP-1 analog (semaglutide) engages two different hormone systems together