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Macromolecular drug-encapsulating NPs can be more efficiently delivered into the AD brain harnessing the AMT mechanism via their surface conjugation with cationic oligos, proteins or basic cell-penetrating peptides for an electrostatic interaction with the negative charged surfaces of the capillary endothelial cells (Lu, 2012

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By combining the local application to the foot with a more systemic approach targeting the lumbar spine, therapists can provide comprehensive support for nerve function, addressing both local symptoms and the underlying nerve pathway