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Since increased anti-oxidative capacity enhances tumorigenesis in various cancer settings, we next focused on cellular redox homeostasis controlled by glutathione (GSH) [33]

These beneficial effects are consistent with the actions of HIF-1 in cardiomyocytes, which include the reactivation of angiogenesis, a shift toward anaerobic metabolism, and a reduction in apoptosis [91]

Emerging approaches involving biomarker panels and multi-omics technologies (such as proteomics and miRNA expression profiling) offer promising avenues for improving diagnostic accuracy

L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase