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1 Introduction In 2024, the International Agency for Research on Cancer (IARC) released the latest GLOBOCAN 2022 database, which encompasses data on the incidence and mortality of 36 types of cancer across 185 countries or regions worldwide

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LHCGR engagement activates Gs-coupled adenylyl cyclase, driving cAMP accumulation and PKA-mediated phosphorylation of downstream steroidogenic targets including CYP11A1, CYP17A1, and 3-HSD

The participants continued to apply 4 sprays (0.5 mL or 100 mg rGSH) of the topical solution twice a day (6 h apart) until the final blood draw 72 h after the initial application