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The pretreatment phase began on day 2 when medium was replaced with medium containing DMSO or a small molecule inhibitor (e.g., nutlin-3 [10 M] or gemcitabine HCL [200 nM])

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The key stroke registration data come from multi-centre Russian clinical trials in the 1990s and 2000s, showing reduced neurological deficit on standardised rating scales and improved functional recovery when intranasal Semax 1 percent was added to standard acute-stroke care within the first 24 hours of symptom onset

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