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This was not a small effect

In respiratory viral infections such as rhinovirus, influenza, etc., deficiencies of IFN- and within the macrophages of airway epithelium and subepithelium correlated with the severities of the viral infection and asthma

The self-assembled Bacteriphage MS2 VLP, which is modified with SP94 peptide and encapsulated with doxorubicin, cisplatin, and 5-fluoro-uracil to selectively transport and kill human hepatocellular carcinoma (HCC) in the Hep3B cell line, is a classic example of VLPs as targeted therapeutic carriers (147)

Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients