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The use of prophylactic antibiotics in necrotizing pancreatitis is not recommended in view of a recent prospective randomized double-blind trial that showed no benefit and in view of the concern that the prolonged use of potent antibiotic agents may lead to the emergence of resistant Gram-positive organisms and fungal infections in the necrotic pancreas

To solve this problem, various means of genetic engineering and synthetic biology have been applied to alleviate host burden, including optimization of the expression intensity of T7 RNAP and pET expression systems (Fig

Some evidence suggests that B12 may help prevent or slow down the development of osteoporosis

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