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doi: 10.1016/j.ijpara.2010.04.004 20 BrussowH

A: The distinction often lies in the temporal relationship between pleasure-seeking behaviors and motivation loss

All patients who ingest 30 g or 500 mg/kg of modified release paracetamol or have a paracetamol concentration greater than double the nomogram line should receive an increased dose of acetylcysteine (that is 200 mg/kg over 16 hours)