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Kochman et al., 2026), (ii) enhance interaction with brain endothelial cells and overcome the BBB for systemic delivery pathway (Guo et al., 2020), while circumvent the mucociliary clearance and enhance nasal permeability for nose-to-brain delivery pathway (Sood et al., 2014

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While the role of HIF in the hypoxia response is well-established [110, 111], further exploration is needed to elucidate the specific regulatory network of HIF in HAPH and its interactions with other molecules and signaling pathways