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In addition, as autophagy may play a protective role against ER stress and rejuvenate organelle function, impaired autophagy may lead to mitochondrial dysfunction and ER stress, which have been implicated as causes of insulin resistance

Based on the skeleton of 2-amino-3-cyano-6-(2-hydroxy-phenyl)pyridine, a series of inhibitors were designed and synthesized, yielding compounds 69-74 [180, 181]

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freundii isolates from a tertiary a hospital in the same area collected from October 2009 to January 2010 we found a plasmid with 100% identity to p121SC21-KPC2 in isolate HULP-6197, and an almost identical plasmid with a 185 bp deletion in the merR gene in C