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In addition, regular blood transfusion therapy is required for thalassemia major patients to maintain adequate hemoglobin concentrations (Viprakasit and Ekwattanakit, 2018)

Attention is focused on the reasons preclinical promise has not translated into clinical success, emphasizing the limitations of current research models, the urgent need for reliable biomarkers of mitochondrial dysfunction, and the complexity of targeting interconnected pathological networks