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British Society of gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma

A.Von FrankenbergA

The hydroxylated HIF-1 is recognized by the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex, leading to its ubiquitination and subsequent rapid degradation via the proteasome pathway, thus maintaining extremely low levels of HIF-1 under normal oxygen tension (Maxwell et al., 1999