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According to the positive pleiotropy hypothesis, it is the endometrium and its controlling mechanisms that determine the degree of trophoblast invasion and dictate the type of placentation in eutherian mammals ( Placental development and pregnancy-related diseases The placenta plays crucial protective roles for the fetus, but its structure and function are also associated with pregnancy complications such as IR, preeclampsia, and eclampsia (166168)

[DOI] [Google Scholar] 251.Vinson J.A., Kharrat H.A., Andreoli L

Adapted from Porsbjerg et al (2023) and Lange-Vaidya & Hartert (2025)

While numerous studies have emphasized its antioxidant, anti-inflammatory, and nephroprotective properties, there is insufficient consensus on the specific bioactive components responsible for these effects or their precise mechanisms of action